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Tumourigenesis within the intestine is potently driven by deregulation of the Wnt pathway, a process epigenetically regulated by the chromatin remodelling factor Brg1.We aimed to investigate this interdependency in an in vivo setting and assess the viability of Brg1 as a potential therapeutic target.Using a range of transgenic approaches, we delete
The release of nanoparticles into the environment can interfere with the health of the exposed organisms.MicroRNAs have been suggested as potential toxicology biomarkers.The expression of potential zebrafish nano-toxicity biomarker miRNAs in our previous study was validated in THP-1 human monocytic cell line after exposure to polystyrene (PSNPs) an